Creature of habit, Jon Smith, spends his days mindlessly working as a barista in New York City. When night falls, this seeming everyman savagely kills "filthy women" as his social outlet. A chance encounter with Delia, a young prostitute searching for an escape from her troubled past, forces Jon to confront the most terrifying thing he has ever faced in all his dark affairs - himself. All God's Creatures examines the true nature of what it means to be a monster and reveals that love is not only for a chosen few, but for all God's creatures.

Claire Smythson, wife of the renowned abstract artist Richard Smythson, is plunged into a late-life crisis when her husband is diagnosed with Alzheimer's disease and is in danger of not completing the paintings for his final show.